LRRTM1
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LRRTM1[1], or Leucine-rich repeat transmembrane neuronal protein 1, is the first gene linked to increased odds of being left-handed[2][3][4]. The researchers also found evidence that possessing one particular variant of this gene slightly raises the risk of psychotic mental illnesses such as schizophrenia[5]. As the name implies, its protein product is a transmembrane protein, which contains many leucine rich repeats, that is present in neurons. It is expressed during the development of specific forebrain structures and shows a variable pattern of maternal downregulation (genomic imprinting).
The original research article from 2007 was published in the journal Molecular Psychiatry: http://www.nature.com/mp/journal/v12/n12/abs/4002053a.html. The researchers who discovered LRRTM1's potential involvement in left-handedness and schizophrenia also released a statement for the press and public in July 2007.
[edit] See also
[edit] References
- ^ NCBI link for LRRTM1
- ^ Francks et al. Molecular Psychiatry (2007) 12: 1129-1139
- ^ LRRTM1: A possible gene for left-handedness « Anthropology.net
- ^ Gene for left-handedness is found , http://news.bbc.co.uk/2/hi/health/6923577.stm, BBC, 31 July 2007
- ^ Gene for Left-Handed Trait Discovered
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