Hormone response element
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A hormone response element (HRE) is a response element for hormones, a short sequence of DNA within the promoter of a gene that is able to bind a specific hormone receptor complex and therefore regulate transcription.[1] The sequence is most commonly a pair of inverted repeats separated by three nucleotides, which also indicates that the receptor binds as a dimer.
A gene may have many different response elements, allowing complex control to be exerted over the level and rate of transcription.[2]
HRE are used in transgenic animal cells as inducer of gene expression.
[edit] Examples
The glucocorticoid response element ("GRE") is "5'-GGTACAnnnTGTTCT-3'". The "n"s refer to positions that don't require a specific nucleotide for binding.[3]
This GRE is shared with mineralocorticoids, progesterone, and androgens, but not estrogen.
[edit] References
- ^ "Steroid Hormone Receptors and their Response Elements". http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/SteroidREs.html. Retrieved on 2006-11-09.
- ^ Monty Krieger; Matthew P Scott; Matsudaira, Paul T.; Lodish, Harvey F.; Darnell, James E.; Lawrence Zipursky; Kaiser, Chris; Arnold Berk (2003). Molecular Cell Biology, Fifth Edition. San Francisco: W. H. Freeman. p. 973 pages. ISBN 0-7167-4366-3.
- ^ Mechanism of Action: Hormones with Intracellular Receptors
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