Booster dose
From Wikipedia, the free encyclopedia
After initial immunization, a booster injection or booster dose is a re-exposure to the immunizing antigen. It is intended to increase immunity against that antigen back to protective levels after it has been shown to have decreased or after a specified period of time. For example, tetanus shot boosters are often recommended every 10 years.[1]
If a patient receives a booster dose, but already has a high level of antibody, then a reaction called an Arthus reaction could develop, a localized form of Type III hypersensitivity, induced by fixation of complement by preformed circulating antibodies. In severe cases, the degree of complement fixation can be so substantial that it induces local tissue necrosis.[2]
[edit] See also
[edit] References
- ^ Tetanus: Prevention, Mayo Clinic, 2006-09-21, http://www.mayoclinic.com/health/tetanus/DS00227/DSECTION=prevention, retrieved on 2008-07-17
- ^ University of the Sciences in Philadelphia, David B. Troy, Joseph Price Remington, Paul Beringer (2005). Remington: the science and practice of pharmacy. Lippincott Williams & Wilkins. ISBN 0781746736.
